{"id":603244,"date":"2024-11-05T22:18:25","date_gmt":"2024-11-05T22:18:25","guid":{"rendered":"https:\/\/pdfstandards.shop\/product\/uncategorized\/iso-200462019\/"},"modified":"2024-11-05T22:18:25","modified_gmt":"2024-11-05T22:18:25","slug":"iso-200462019","status":"publish","type":"product","link":"https:\/\/pdfstandards.shop\/product\/publishers\/iso\/iso-200462019\/","title":{"rendered":"ISO 20046:2019"},"content":{"rendered":"<p>The purpose of this document is to provide criteria for quality assurance (QA), quality control (QC) and evaluation of the performance of biological dosimetry by cytogenetic service laboratories.<\/p>\n<p>This document addresses:<\/p>\n<p>a)    the responsibilities of both the customer and the laboratory;<\/p>\n<p>b)    the confidentiality of personal information, for the customer and the laboratory;<\/p>\n<p>c)    the laboratory safety requirements;<\/p>\n<p>d)    sample processing; culturing, staining and scoring, including the criteria for scoring for translocation analysis by FISH;<\/p>\n<p>e)    the calibration sources and calibration dose ranges useful for establishing the reference dose-response curves that contribute to the dose estimation from chromosome aberration frequency and the detection limit;<\/p>\n<p>f)     the scoring procedure for translocations stained by FISH used for evaluation of exposure;<\/p>\n<p>g)    the criteria for converting a measured aberration frequency into an estimate of absorbed dose (also appears as &#034;dose&#034;);<\/p>\n<p>h)    the reporting of results;<\/p>\n<p>i)     the QA and QC;<\/p>\n<p>j)     Annexes A to F containing sample instructions for the customer, sample questionnaire, sample datasheet for recording aberrations, sample of report and fitting of the low dose-response curve by the method of maximum likelihood and calculating the uncertainty of dose estimate.<\/p>\n","protected":false},"excerpt":{"rendered":"<p><b>Radiological protection \u2014 Performance criteria for laboratories using Fluorescence In Situ Hybridization (FISH) translocation assay for assessment of exposure to ionizing radiation<\/b><\/p>\n<table style=\"width: 100%\" border=\"0\" cellspacing=\"0\" cellpadding=\"0\">\n<tbody>\n<tr>\n<td>Published By<\/td>\n<td>Publication Date<\/td>\n<td>Number of Pages<\/td>\n<\/tr>\n<tr>\n<td><a href=\"https:\/\/pdfstandards.shop\/product-category\/publishers\/iso\/\"><b>ISO<\/b><\/a><\/td>\n<td>2019-03<\/td>\n<td>48<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n","protected":false},"featured_media":603256,"template":"","meta":{"rank_math_lock_modified_date":false,"ep_exclude_from_search":false},"product_cat":[245,2634],"product_tag":[],"class_list":{"0":"post-603244","1":"product","2":"type-product","3":"status-publish","4":"has-post-thumbnail","6":"product_cat-13-280","7":"product_cat-iso","9":"first","10":"instock","11":"sold-individually","12":"shipping-taxable","13":"purchasable","14":"product-type-simple"},"_links":{"self":[{"href":"https:\/\/pdfstandards.shop\/wp-json\/wp\/v2\/product\/603244","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/pdfstandards.shop\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/pdfstandards.shop\/wp-json\/wp\/v2\/types\/product"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/pdfstandards.shop\/wp-json\/wp\/v2\/media\/603256"}],"wp:attachment":[{"href":"https:\/\/pdfstandards.shop\/wp-json\/wp\/v2\/media?parent=603244"}],"wp:term":[{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/pdfstandards.shop\/wp-json\/wp\/v2\/product_cat?post=603244"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/pdfstandards.shop\/wp-json\/wp\/v2\/product_tag?post=603244"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}