BSI PD ISO/TR 22019:2019
$198.66
Nanotechnologies. Considerations for performing toxicokinetic studies with nanomaterials
| Published By | Publication Date | Number of Pages |
| BSI | 2019 | 64 |
This document describes the background and principles for toxicokinetic studies relevant for nanomaterials.
Annex A shows the definitions for terminology with respect to toxicokinetics as used in OECD TG 417:2010.
PDF Catalog
| PDF Pages | PDF Title |
|---|---|
| 2 | National foreword |
| 6 | Foreword |
| 7 | Introduction |
| 9 | 1 Scope 2 Normative references 3 Terms and definitions |
| 11 | 4 Abbreviations 5 Importance of toxicokinetic information for risk assessment of nanomaterials 5.1 General |
| 12 | 5.2 Possible use of toxicokinetic information |
| 13 | 5.3 Key toxicokinetic issues for nanomaterials 6 Factors influencing the toxicokinetics of nanomaterials 6.1 Dissolution rate |
| 14 | 6.2 Physical chemical properties determinant for toxicokinetic behavior |
| 18 | 7 Analytical challenges 7.1 General 7.2 Analysis of element |
| 19 | 7.3 Analysis of element radiolabel or fluorescence label |
| 20 | 7.4 Determination of particles |
| 21 | 7.5 Limit of detection 8 Issues relevant for dosing conditions 8.1 General |
| 22 | 8.2 Dose metrics |
| 23 | 9 Absorption of nanomaterials 9.1 General 9.2 Skin |
| 24 | 9.3 Gastrointestinal (GI) tract |
| 26 | 9.4 Respiratory tract |
| 30 | 10 Distribution 10.1 General 10.2 Organ distribution |
| 31 | 10.3 Transport across the placenta, BBB and to reproductive organs |
| 32 | 11 Metabolism/degradation 12 Excretion |
| 33 | 13 Conclusions |
| 37 | Annex A (informative) Definitions as used in OECD Test Guideline 417:2010 |
| 40 | Annex B (informative) Quantitation methods for nanomaterials, advantages and challenges |
| 47 | Bibliography |
