BSI PD ISO/TR 13014:2012
$167.15
Nanotechnologies. Guidance on physico-chemical characterization of engineered nanoscale materials for toxicologic assessment
| Published By | Publication Date | Number of Pages |
| BSI | 2012 | 44 |
This Technical Report provides guidance for the physico-chemical characterization of manufactured nano- objects and their aggregates and agglomerates (NOAA) greater than 100 nm presented for toxicological testing in order to aid in assessing and interpreting the toxicological impact of manufactured nano-objects and to allow the material under test to be differentiated from seemingly similar materials. For each of the selected properties, a description, clarification, relevance, measurand and example measurement methods are provided.
This Technical Report will be of value to parties (e.g. toxicologists, ecotoxicologists, regulators, health and safety professionals) interested in assessing and interpreting the potential toxicological effect of manufactured NOAAs.
PDF Catalog
| PDF Pages | PDF Title |
|---|---|
| 3 | CVP_Secretariat_Loca |
| 6 | Foreword |
| 7 | Introduction |
| 9 | 1 Scope 2 Terms and definitions |
| 14 | 3 Symbols and abbreviated terms 4 Importance of physico-chemical properties to toxicological assessment 4.1 The purpose of toxicological experimentation |
| 15 | 4.2 General methods of toxicological testing and risk assessment |
| 16 | 4.3 Physico-chemical properties of nano-objects |
| 17 | 4.4 Purity and impurity of tested nano-objects 4.5 When to undertake physico-chemical characterization |
| 18 | 4.6 Potential problems with materials assessment |
| 19 | 5 Parameters for the physico-chemical characterization of manufactured nano-objects prior to toxicological assessment 5.1 General information 5.2 Particle size and particle size distribution |
| 20 | 5.3 Aggregation/agglomeration state in relevant media |
| 21 | _Hlk289081596 5.4 Shape |
| 22 | 5.5 Surface area / mass-specific surface area / volume-specific surface area |
| 23 | 5.6 Composition |
| 24 | 5.7 Surface chemistry 5.8 Surface charge |
| 25 | 5.9 Solubility/dispersibility |
| 27 | 6 Expression of measurement results and uncertainties 6.1 General 6.2 Quantifying uncertainty |
| 28 | 6.3 Application of uncertainty to nano-objects 6.4 Importance of validation |
| 29 | 7 Reporting |
| 31 | Annex A (informative) Diagram illustrating the use of physico-chemical characterization in toxicological testing |
| 32 | Annex B (informative) Example measurement methods and standards |
| 38 | Bibliography |
